What is Stereology?

Posted: 13 Jan 03

This article is reproduced, with permission, from Lars Karlsson's website:
http://anatom1.unibe.ch/karlsson

Quote Quote Stereology is a spatial version of sampling theory.

Baddeley, A.J. Stereology. In: Spatial Statistics and Digital Image Analysis, chapter 10, pp.181--216. National Research Council, Washington DC, 1991.

Quote Quote Stereology originated as the problem of studying a three-dimensional physical object from random two-dimensional plane sections or projections, and in particular of estimating geometrical parameters such as volume, surface area, length and total curvature.

Baddeley, A.J. Stereology and survey sampling theory. Bull. Intern. Statis. Inst., Proceedings 49th Session,Florence 1993. 50 (2): 435--449, 1993.

Quote Quote Modern stereology can be regarded as sampling theory for spatial processes.

Baddeley, A.J. Stereology and survey sampling theory. Bull. Intern. Statis. Inst., Proceedings 49th Session,Florence 1993. 50 (2): 435--449, 1993.

Quote Quote Stereology is a body of mathematical methods relating three-dimensional parameters defining the structure to two-dimensional measurements obtainable on sections of the structure.

Bertram, J.F. and Nurcombe, V. Counting cells with the new stereology. Trends Cell. Biol. 2: 177--180, 1992.

Quote Quote A methodology for obtaining quantitative information of a geometric-statistical nature from an object, using sections or projections of the object.

Cruz-Orive, L.M. Introduction to Stereology. Lecture Notes. Department of Anatomy, University of Berne, 1988--89.

Quote Quote As a methodology: "Estimation of geometrical parameters of spatial structures using properly sampled information". As a science: "A combination of geometrical probability and statistics". As a liberal art: "Fun" (at least to the author of these notes).

Cruz-Orive, L.M. Introduction to Stereology. Lecture Notes. Department of Anatomy, University of Berne 1986--94.

Quote Quote Stereology is a very general collection of principles based on integral geometry, probability theory and sampling theory, as opposed to "techniques" or ad-hoc "methods". Stereology may therefore grow by the incorporation of new principles but, like Euclid's Elements, stereology will be well alive after the last scanning instrument, as we know it today, has fallen into oblivion.

Cruz-Orive, L.M. Discussion of topic IN22: Stereology. Bull. Intern. Statis. Inst., Proceedings 49th Session, Florence 1993. 55(4): 162, 1993.

Quote Quote "Stereology", or the generalization of planar structure measurements to three dimensions, ...

Harrigan, T.P. and Mann, R.W. Characterization of microstructural anisotropy in orthotropic materials using a second rank tensor. J. Mater. Sci. 19: 761--767, 1984.

Quote Quote Stereology, a branch of applied geometric probability, concerns the determination of internal geometric properties of a three-dimensional object from lower-dimensional information such as that provided by a planar section through the object.

Jensen, E.B. Design- and model-based stereological analysis of arbitrarily shaped particles. Scand. J. Statist. 14: 161--180, 1987.

Quote Quote Stereological methods concern the estimation of quantitative properties of spatial materials from lower-dimensional information such as that generated by a section through the material.

Jensen, E.B. and Gundersen, H.J.G. The Stereological Estimation of Moments of Particle Volume. J. Appl. Prob. 22: 82--98, 1985.

Quote Quote ...in stereology, "applied geometrical probability", which show...

Jensen, E.B., Baddeley, A.J., Gundersen, H.J.G. and Sundberg, R. Recent Trends in Stereology. Intern. Statist. Rev. 53: 99--108, 1985.

Quote Quote ...stereology is sampling in three dimensions...

Karlsson, L.M. and Cruz-Orive, L.M. Estimation of Pore Size in Aluminium using the Disector, the Selector and Cavalieri's Principle. MiCon 90: Advances in Video Technology for Microstructural Control. ASTM STP 1094 (ed. G.F. Van der Voort), pp. 277--291. American Society for Testing and Materials, Philadelphia, 1991.

Quote Quote Stereology is concerned with the estimation of meaningful quantities defined in a three-dimensional (3-D) structure from measurements made in a proper sample of the structure.

Karlsson, L.M. and Cruz-Orive, L.M. The New Stereological Tools in Metallography: Estimation of Pore Size and Number in Aluminium. J. Microsc. 165: 391--415, 1992.

Quote Quote ...stereology is sometimes regarded as "sampling theory for populations exhibiting a geometrical structure."

Kubinova, L. Advantages of Stereological Methods in Biomedicine. IEEE Engineering in Medicine and Biology March/April: 110--115, 1998.

Quote Quote ... a topic in applied mathematics known as stereology.

Roberts, N., Barbosa, S., Blumhardt, L.D., Kawoski, R.A. and Edwards, R.H.T. Stereological estimation of the total volume of MR visible brain lesions in patients with multiple sclerosis. MAGMA 2: 375--378, 1994.

Quote Quote The objective of stereology is to draw inferences about the geometrical properties of three-dimensional structures when information is only available in some lower-dimensional form via linear probes, planar sections, or projections of thin slices.

Stoyan, D., Kendall, W.S. and Mecke, J. Stochastic Geometry and its Applications. J. Wiley & Sons, Chichester, 1995.

Quote Quote The science of stereology is dealing with the transformation of two-dimensional observations to three-dimensional information, using mathematical, statistical, and geometrical tools.

Vesterby, A. Star volume in bone research. A histomorphometric analysis of trabecular bone structure using vertical sections. Anat. Rec. 235: 325--334, 1993.

Quote Quote At a practical level, stereological methods are precise tools for obtaining quantitative information about three-dimensional structures based on sections.

Vesterby, A. Star volume in bone research. A histomorphometric analysis of trabecular bone structure using vertical sections. Anat. Rec. 235: 325--334, 1993.

Quote Quote Stereology is a body of mathematical methods relating three-dimensional parameters defining the structure to two-dimensional measurements obtainable on sections of the structure.

Weibel, E.R. Stereological Methods, Vol. 1. Practical Methods for Biological Morphometry. Academic Press, London , 1979.
Weibel, E.R. Stereological Methods, Vol. 2. Theoretical Fundations. Academic Press, London, 1980.

Quote Quote ...the word "Stereology" was invented to describe the set of methods that allow a 3D interpretation of structures based on observations made on 2D sections.

Weibel, E.R. Stereology in perspective: a mature science evolves. Acta Stereol. 11/Suppl. I: 1--13, 1992.

Quote Quote Stereology is a body of procedures, mainly geometrical-statistical, which have in mind the aim of obtaining information about three-dimensional structures from two-dimensional, flat images. It can also be defined as extrapolation from two- to three-dimensional space.

Weibel, E.R. and Elias, H. Quantitative Methods in Morphology, Springer, Berlin, 1967.

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